Soluble thrombomodulin activity and soluble thrombomodulin antigen in plasma
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چکیده
منابع مشابه
Soluble thrombomodulin activity and soluble thrombomodulin antigen in plasma.
Endothelial cell membrane-bound thrombomodulin (TM) plays a critical role as a cofactor in the protein C pathway, important in regulating coagulation as well as inflammation. Heterogeneous soluble TM fragments circulate in the plasma and are found at increased levels in various diseases such as cardiovascular disease and diabetes, and in ischemic and/or inflammatory endothelial injuries. The an...
متن کاملSoluble thrombomodulin protects ischemic kidneys.
Altered coagulation and inflammation contribute to the pathogenesis of ischemic renal injury. Thrombomodulin is a necessary factor in the anticoagulant protein C pathway and has inherent anti-inflammatory properties. We studied the effect of soluble thrombomodulin (sTM) in a hypoperfusion model of ischemic kidney injury. To markedly reduce infrarenal aortic blood flow and femoral arterial press...
متن کاملSoluble thrombomodulin and brain infarction: case-control and prospective study.
BACKGROUND AND PURPOSE Increased soluble thrombomodulin (sTM) concentration has been associated with recurrent coronary events, whereas in one prospective study it predicted fewer first-ever coronary events. One study found no relationship between brain infarction (BI) and sTM levels. Among all subjects of the Etude du Profil Génétique de l'Infarctus Cérébral (GENIC) cohort and those free of pr...
متن کاملSoluble thrombomodulin concentration is raised in scleroderma associated pulmonary hypertension.
OBJECTIVE To investigate the expression of thrombomodulin in scleroderma associated pulmonary hypertension. METHODS Soluble thrombomodulin (sTM), was measured in plasma samples from 34 scleroderma patients shown to have pulmonary hypertension at echocardiogram, and comparison drawn against samples from 38 scleroderma control patients, and 20 healthy controls. Serial measurements of sTM were p...
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ORTHOTOPIC liver transplantation (OLT) is now being performed with improved survival rates in a high number of patients suffering from different liver diseases. Despite better control of blood loss, hemorrhages still occur, particularly after reperfusion. Problems arising from defective hemostasis during major abdominal surgery are a major risk for patients with terminal chronic liver disease. ...
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ژورنال
عنوان ژورنال: Journal of Thrombosis and Haemostasis
سال: 2005
ISSN: 1538-7933,1538-7836
DOI: 10.1111/j.1538-7836.2005.01267.x